A new approach to convenient and efficient farm management

A new approach to convenient and efficient farm management

Setting new standards in integrated pest management

Setting new standards in integrated pest management

Systemicity – Translocation

Using a unique formulation concept, SIVANTO® prime 200 SL (soluble liquid) is based on a specifically tailored emulgator system that has never been used before within the agrochemical industry.

Based on the excellent spontaneity of SIVANTO® prime’s formulation rapid solubility and good miscibility takes place in the spray tank avoiding any precipitation and forming a homogenous solution. After spray application the advanced retention which means the ability to retain the compound on the plant surface due to the unique emulgator system results into high bioavailability and enhanced plant penetration of the active ingredient for rapid activity. The improved cold stability of the formulation leads to easy handling and storage of the produce even at low temperature.

Translaminar and xylem-systemic movement

SIVANTO® prime’s active ingredient is taken up into the leaves and stems with spray application and via the roots when applied to soil or alternative substrates. After absorption into the plant, SIVANTO® prime is translocated acropetally in the xylem, in the direction of the transpiration stream, and is translaminarily distributed into adjacent plant cells.

Due to this translaminar movement, it is successful against insects feeding on the underside, even when applied only to the topside of the leaf.

Contact, feeding and translaminar efficacy

Hard-to-reach spots and pests are no longer a problem

Compared to standard competitors, SIVANTO® prime provides very fast feeding cessation (measured by honeydew excretion) even on aphids feeding on the underside of leaves.

Contact & feeding
Crop Pest Rate Contact & feeding
Pepper Myzus persicae 60g a.i./ha ++++
Pepper Myzus persicae 12g a.i./ha ++++
spray droplet on lower leaf surface
Translaminar
Crop Pest Rate Translaminar
Cotton Aphis gossypii 75g a.i./ha +++
Cabbage Myzus persicae 75g a.i./ha ++++
spray droplet on upper leaf surface

Foliar application: SIVANTO® prime’s systemic translocation properties distributes the active substance rapidly throughout the leaves to reach even hidden pests.

Mode of Action

As an agonist of the insect nicotinic acetylcholine receptor (nAChR), flupyradifurone mimics the natural neurotransmitter acetylcholine.

  1. Nerve connections in the central nervous system of insects.
  2. Neurotransmitter release from pre-synaptic vesicles and their binding to post-synaptic nAChRs.
  3. SIVANTO® prime binds to and opens the post-synaptic nAChR.

The action of SIVANTO® prime takes place in the central nerve system of targeted insect pests. Here the active ingredient flupyradifurone acts as an agonist which means that the chemical binds to a receptor and activates the receptor to produce a biological response. Flupyradifurone acts like the naturally occurring neurotransmitter acetylcholine (here shown as red dots in the graphic), and the binding to the receptor protein induces a depolarizing ion current, causing excitation of the nerve cell. In contrast to acetylcholine, flupyradifurone cannot be inactivated by the respective enzyme acetylcholinesterase, which leads to a permanent opening of the post-synaptic receptor. The lasting effect of the product results in a disorder of the insect nervous system and subsequent collapse.

Classification

With its unique pharmacophore system, flupyradifurone is chemically distinct from neonicotinoid insecticides and sulfoxaflor

Flupyradifurone is a butenolide insecticide with a distinct new chemistry and has been assigned to IRAC (Insecticide Resistance Action Committee) mode of action Group 4D, a new subgroup of Group 4, which includes all insecticidal agonists of nAChR. It binds to the nAChR but with a different pharmacophore than neonicotinoids (4A) and sulfoximines (4C). Thus, flupyradifurone presents little to no metabolism-based cross-resistance with neonicotinoids in target species.

However, target-site mutation-based cross-resistance affects all compounds within IRAC group 4. This results in loss of sensitivity in target pests. Therefore, a clear resistance management strategy has been developed to keep SIVANTO® prime working against neonicotinoid-resistant populations (e.g. whiteflies).

IRAC Classification

Neonicotinoids 4A

Nitroguanidines

  • Imidacloprid
  • Thiamethoxam
  • Clothianidin
  • Dinotefuran
Nitroguanidines

Nitromethylenes

  • Nitenpyram
Nitromethylenes

N-cyanoamidines

  • Thiacloprid (E=SCH2CH2)
  • Acetamiprid (E=CH2)
N-Cyanoamidines

Sulfoximines 4C

Sulfoxaflor

Sulfoximines

Butenolides 4D

Flupyradifurone

Butenolides

The butenolide pharmacophore is a new bioactive scaffold for commercial nAChR agonists.